Title : ERBB2 Is Essential for the Growth of Chemically Induced Skin Tumors in Mice.

Pub. Date : 2017 Apr

PMID : 27931797






2 Functional Relationships(s)
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1 Compared with control littermates, Erbb2del mice remained free of papillomas for a longer time and had significantly reduced tumor burden after application of the 7,12-dimethylbenz[a]anthracene/12-O-tetradecanoylphorbol-13-acetate multistage chemical carcinogenesis protocol. Tetradecanoylphorbol Acetate erb-b2 receptor tyrosine kinase 2 Mus musculus
2 Furthermore, tumor cell proliferation was substantially reduced in Erbb2del mice, and loss of ERBB2 also decreased keratinocyte proliferation after 12-O-tetradecanoylphorbol-13-acetate application. Tetradecanoylphorbol Acetate erb-b2 receptor tyrosine kinase 2 Mus musculus