Title : Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study.

Pub. Date : 2017 Mar

PMID : 27928738






2 Functional Relationships(s)
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1 Effect of Multiple Oral Doses of the Potent CYP3A4 Inhibitor Clarithromycin on the Pharmacokinetics of a Single Oral Dose of Vonoprazan: A Phase I, Open-Label, Sequential Design Study. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 CONCLUSIONS: Modest increases in plasma concentrations of the potent CYP3A4 inhibitor clarithromycin and vonoprazan were observed during coadministration, however these differences were not considered clinically significant. Clarithromycin cytochrome P450 family 3 subfamily A member 4 Homo sapiens