Title : Design, synthesis and analgesic/anti-inflammatory evaluation of novel diarylthiazole and diarylimidazole derivatives towards selective COX-1 inhibitors with better gastric profile.

Pub. Date : 2017 Jan 15

PMID : 27916468






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1 Two novel series of 4,5-diarylthiazole and diarylimidazole were designed, synthesized in analogy to selective COX-1 inhibitors (mofezolac and FR122047) which lack gastric damaging effects. mofezolac prostaglandin-endoperoxide synthase 1 Homo sapiens