Title : CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia.

Pub. Date : 2017 Feb

PMID : 27913861






1 Functional Relationships(s)
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1 This study supports the rationale to combine CXCR4 inhibitors and PD-1 immune checkpoint inhibitors in patients with HCC, as sorafenib-induced tumour hypoxia leads to upregulation of PD-L1 and CXCL12. Sorafenib CD274 molecule Homo sapiens