PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27913861-10 2017 This study supports the rationale to combine CXCR4 inhibitors and PD-1 immune checkpoint inhibitors in patients with HCC, as sorafenib-induced tumour hypoxia leads to upregulation of PD-L1 and CXCL12. Sorafenib 125-134 CD274 molecule Homo sapiens 183-188