Pub. Date : 2016 Nov 10
PMID : 27911399
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we use a TFO covalently conjugated on the 5" end to a 4"-hydroxymethyl-4,5",8-trimethylpsoralen (HMT) psoralen to generate a site-specific ICL on a mutation-reporter plasmid to use as a tool to study the architectural modification, processing, and repair of complex DNA lesions by HMGB1 in human cells. | tfo | high mobility group box 1 | Homo sapiens |
| 2 | We describe experimental techniques to prepare TFO-directed ICLs on reporter plasmids, and to interrogate the association of HMGB1 with the TFO-directed ICLs in a cellular context using chromatin immunoprecipitation assays. | tfo | high mobility group box 1 | Homo sapiens |