Title : Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells.

Pub. Date : 2017 Mar

PMID : 27908642






2 Functional Relationships(s)
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1 Importantly, gene silencing of SIRT1 abrogated the inhibitory effect of SIRT1 activator on NLRP3 inflammasome formation and IL-1beta production in HUVECs stimulated with LPS plus ATP. Adenosine Triphosphate sirtuin 1 Homo sapiens
2 Importantly, gene silencing of SIRT1 abrogated the inhibitory effect of SIRT1 activator on NLRP3 inflammasome formation and IL-1beta production in HUVECs stimulated with LPS plus ATP. Adenosine Triphosphate sirtuin 1 Homo sapiens