Title : A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC.

Pub. Date : 2016 Dec 1

PMID : 27906178






2 Functional Relationships(s)
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1 The synergistic and potent anti-tumor efficacy observed between DOX and thiosemicarbazones represents a promising treatment combination for advanced cancers, which are heterogeneous and composed of non-Pgp- and Pgp-expressing tumor cells. Thiosemicarbazones ATP binding cassette subfamily B member 1 Homo sapiens
2 The synergistic and potent anti-tumor efficacy observed between DOX and thiosemicarbazones represents a promising treatment combination for advanced cancers, which are heterogeneous and composed of non-Pgp- and Pgp-expressing tumor cells. Thiosemicarbazones ATP binding cassette subfamily B member 1 Homo sapiens