Pub. Date : 2016
PMID : 27904045
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Puerarin Prevents LPS-Induced Osteoclast Formation and Bone Loss via Inhibition of Akt Activation. | puerarin | toll-like receptor 4 | Mus musculus |
| 2 | In this study, we assessed the effect of puerarin, a natural isoflavone isolated from Pueraria lobata OHWI root, on LPS-induced osteoclastogenesis and bone loss. | puerarin | toll-like receptor 4 | Mus musculus |
| 3 | Our in vitro study showed that puerarin significantly inhibited LPS-induced osteoclast differentiation from osteoclast precursor RAW264.7 cells. | puerarin | toll-like receptor 4 | Mus musculus |
| 4 | Furthermore, LPS triggered activation of Akt in osteoclast precursor RAW264.7 cells, which was inhibited by puerarin treatment. | puerarin | toll-like receptor 4 | Mus musculus |
| 5 | In vivo, puerarin attenuated LPS-induced bone loss in a murine calvarial osteolysis model. | puerarin | toll-like receptor 4 | Mus musculus |
| 6 | Collectively, puerarin prevents LPS-induced osteoclast formation, function and bone loss, where the inhibition of Akt activation plays an important role. | puerarin | toll-like receptor 4 | Mus musculus |