Title : PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide.

Pub. Date : 2017 Jan 3

PMID : 27903966






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 PDE5 inhibitors enhance the lethality of pemetrexed through inhibition of multiple chaperone proteins and via the actions of cyclic GMP and nitric oxide. Nitric Oxide phosphodiesterase 5A Homo sapiens
2 Phosphodiesterase 5 (PDE5) inhibitors prevent the breakdown of cGMP that results in prolonged protein kinase G activation and the generation of nitric oxide. Nitric Oxide phosphodiesterase 5A Homo sapiens
3 Phosphodiesterase 5 (PDE5) inhibitors prevent the breakdown of cGMP that results in prolonged protein kinase G activation and the generation of nitric oxide. Nitric Oxide phosphodiesterase 5A Homo sapiens