Title : Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells.

Pub. Date : 2017 Mar 21

PMID : 27902968






1 Functional Relationships(s)
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1 Mechanistically, selenite promotes association of APC/C-CDH1 with GLS1 and leads to GLS1 degradation by ubiquitination, this process is related to induction of PTEN expression. Selenious Acid phosphatase and tensin homolog Homo sapiens