Pub. Date : 2017 Feb 17
PMID : 27865780
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we design genetically encoded antibody-like ligands (intrabodies) that recognize active, GTP-bound K- and H-Ras. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |
| 2 | Primary selection of ligands against Ras with mRNA display resulted in an intrabody (termed RasIn1) that binds with a KD of 2.1muM to H-Ras(G12V) (GTP), excellent state selectivity, and remarkable specificity for K- and H-Ras. | Guanosine Triphosphate | HRas proto-oncogene, GTPase | Homo sapiens |