Title : Adipocytes secreted leptin is a pro-tumor factor for survival of multiple myeloma under chemotherapy.

Pub. Date : 2016 Dec 27

PMID : 27863383






1 Functional Relationships(s)
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1 Next, by using co-culture system of myeloma and adipocytes, and pharmacologic enhancement of leptin, we found that increased growth of myeloma cells and reduced toxicity of bortezomib were best observed at 50 ng/ml of leptin, along with increased expression of cyclinD1, Bcl-2 and decreased caspase-3 expression. Bortezomib caspase 3 Homo sapiens