Title : Benzyloxynitrostyrene analogues - A novel class of selective and highly potent inhibitors of monoamine oxidase B.

Pub. Date : 2017 Jan 5

PMID : 27855360






2 Functional Relationships(s)
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1 This study shows that the 3-benzyloxy-beta-nitrostyrene analogues are potent inhibitors of the MAO-B isoform with IC50 values in the nanomolar range (39-565 nM). 3-benzyloxy-beta-nitrostyrene monoamine oxidase B Homo sapiens
2 Since some of the 3-benzyloxy-beta-nitrostyrene analogues possess potencies that are comparable to that of the reversible inhibitor, safinamide (IC50 = 0.080 muM), it may be concluded that this class may be promising leads for the development of reversible and selective MAO-B inhibitors, that may be useful for the management of Parkinson"s disease. 3-benzyloxy-beta-nitrostyrene monoamine oxidase B Homo sapiens