Pub. Date : 2017 Jan 5
PMID : 27855360
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This study shows that the 3-benzyloxy-beta-nitrostyrene analogues are potent inhibitors of the MAO-B isoform with IC50 values in the nanomolar range (39-565 nM). | 3-benzyloxy-beta-nitrostyrene | monoamine oxidase B | Homo sapiens |
2 | Since some of the 3-benzyloxy-beta-nitrostyrene analogues possess potencies that are comparable to that of the reversible inhibitor, safinamide (IC50 = 0.080 muM), it may be concluded that this class may be promising leads for the development of reversible and selective MAO-B inhibitors, that may be useful for the management of Parkinson"s disease. | 3-benzyloxy-beta-nitrostyrene | monoamine oxidase B | Homo sapiens |