Title : Depression induces poor prognosis associates with the down-regulation brain derived neurotrophic factor of serum in advanced small cell lung cancer.

Pub. Date : 2016 Dec 27

PMID : 27852063






1 Functional Relationships(s)
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1 Using the MTT cell viability assay in vitro, we observed that cotreatment with BDNF clearly enhanced the chemosensitivity of NCI-H69 tumor cells to Cisplatin and induced the downregulation of ABCG2.Based on this evidence, it appears that a relationship does exist between depression and prognosis in SCLC and that the mechanism by which depression affects prognosis is achieved via the downregulation of BDNF expression. monooxyethylene trimethylolpropane tristearate brain derived neurotrophic factor Homo sapiens