Title : Fenretinide inhibits macrophage inflammatory mediators and controls hypertension in spontaneously hypertensive rats via the peroxisome proliferator-activated receptor gamma pathway.

Pub. Date : 2016

PMID : 27843299






2 Functional Relationships(s)
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1 In addition, LPS-induced pro-inflammatory cytokine production, including tumor necrosis factor-alpha, interleukin 6, and monocyte chemoattractant protein 1 were dose-dependently reversed by fenretinide, and the effects of fenretinide on LPS-induced pro-inflammatory cytokine production were blocked by treatment with PPARgamma antagonist. Fenretinide interleukin 6 Rattus norvegicus
2 In addition, LPS-induced pro-inflammatory cytokine production, including tumor necrosis factor-alpha, interleukin 6, and monocyte chemoattractant protein 1 were dose-dependently reversed by fenretinide, and the effects of fenretinide on LPS-induced pro-inflammatory cytokine production were blocked by treatment with PPARgamma antagonist. Fenretinide interleukin 6 Rattus norvegicus