Pub. Date : 2017 Feb 23
PMID : 27841867
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The ROCK inhibitor, Y-27632, was identified and validated for selective targeting of VHL-deficient CC-RCC in multiple genetic backgrounds by clonogenic assays. | Y 27632 | Rho associated coiled-coil containing protein kinase 1 | Homo sapiens |
| 2 | Downregulation of ROCK1 by small interfering RNA (siRNA) selectively reduced the colony-forming ability of VHL-deficient CC-RCC, thus mimicking the effect of Y-27632 treatment, whereas downregulation of ROCK2 had no effect. | Y 27632 | Rho associated coiled-coil containing protein kinase 1 | Homo sapiens |