Title : Two proofreading steps amplify the accuracy of genetic code translation.

Pub. Date : 2016 Nov 29

PMID : 27837019






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 First, aa-tRNAs in ternary complex with EF-Tu GDP are selected in a step where the accuracy increases linearly with increasing aa-tRNA affinity to EF-Tu. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
2 First, aa-tRNAs in ternary complex with EF-Tu GDP are selected in a step where the accuracy increases linearly with increasing aa-tRNA affinity to EF-Tu. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
3 Then, following dissociation of EF-Tu GDP from the ribosome, the accuracy is further increased in a second and apparently EF-Tu-independent step. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens
4 Then, following dissociation of EF-Tu GDP from the ribosome, the accuracy is further increased in a second and apparently EF-Tu-independent step. Guanosine Diphosphate eukaryotic translation elongation factor 1 alpha 1 Homo sapiens