Title : Neuroprotective effects of sildenafil against oxidative stress and memory dysfunction in mice exposed to noise stress.

Pub. Date : 2017 Feb 15

PMID : 27836585






1 Functional Relationships(s)
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1 Interestingly, sildenafil administration increased memory performance, decreased oxidative stress, and increased neuroprotection in the hippocampus region of noise alone-induced mice likely through affecting memory related pathways such as cGMP/PKG/CREB and p25/CDK5, and induction of free radical scavengers such as SOD1, SOD2, SOD3, Prdx5, and catalase in the brain of stressed mice. Sildenafil Citrate cAMP responsive element binding protein 1 Mus musculus