Title : Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway.

Pub. Date : 2017 Mar

PMID : 27834952






1 Functional Relationships(s)
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1 Thus, our results suggest that polyI:C activates the TLR3/TICAM-1 and IFNAR signaling pathways in CD11b+Ly6G+ cells in tumors, thereby eliciting their antitumor activity, independent of those in CD8alpha+/CD103+ DCs that prime CTLs. Poly I-C TIR domain containing adaptor molecule 1 Homo sapiens