Title : Ontogeny of Norepinephrine Transporter Expression and Antidepressant-Like Response to Desipramine in Wild-Type and Serotonin Transporter Mutant Mice.

Pub. Date : 2017 Jan

PMID : 27831486






5 Functional Relationships(s)
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1 We investigated the relation between antidepressant-like response to the TCA desipramine using the tail suspension test and saturation binding of [3H]nisoxetine to the norepinephrine transporter (NET), the primary target of desipramine, in juvenile (21 days postnatal [P21]), adolescent (P28), and adult (P90) wild-type (SERT+/+) mice. Desipramine solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus
2 We investigated the relation between antidepressant-like response to the TCA desipramine using the tail suspension test and saturation binding of [3H]nisoxetine to the norepinephrine transporter (NET), the primary target of desipramine, in juvenile (21 days postnatal [P21]), adolescent (P28), and adult (P90) wild-type (SERT+/+) mice. Desipramine solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus
3 We investigated the relation between antidepressant-like response to the TCA desipramine using the tail suspension test and saturation binding of [3H]nisoxetine to the norepinephrine transporter (NET), the primary target of desipramine, in juvenile (21 days postnatal [P21]), adolescent (P28), and adult (P90) wild-type (SERT+/+) mice. Desipramine solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus
4 These data show age-dependent shifts for desipramine to produce antidepressant-like effects that correlate with NET expression in the locus coeruleus and suggest that drugs with NET-blocking activity may be an effective alternative to SSRIs in juveniles. Desipramine solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus
5 These data show age-dependent shifts for desipramine to produce antidepressant-like effects that correlate with NET expression in the locus coeruleus and suggest that drugs with NET-blocking activity may be an effective alternative to SSRIs in juveniles. Desipramine solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Mus musculus