Title : The Val158Met polymorphism in COMT gene and cancer risk: role of endogenous and exogenous catechols.

Pub. Date : 2017 Feb

PMID : 27826992






2 Functional Relationships(s)
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1 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. Quercetin catechol-O-methyltransferase Homo sapiens
2 Whereas, the diverse anticancer activities of common phytochemicals, such as green tea polyphenols, quercetin, fisetin or luteolin, can be markedly changed (both decreased or increased) by the COMT-mediated O-methylation of these exogenous substrates, flavonoids can also behave as potent inhibitors of the COMT enzyme slowing detoxification of endogenous catechol estrogens. Quercetin catechol-O-methyltransferase Homo sapiens