Title : Plant-derived triterpene celastrol ameliorates oxygen glucose deprivation-induced disruption of endothelial barrier assembly via inducing tight junction proteins.

Pub. Date : 2016 Dec 1

PMID : 27823626






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Celastrol induced occludin, claudin-5 and zonula occludens-1 (ZO-1) in endothelial cells. celastrol occludin Mus musculus
2 Further mechanistic studies revealed that celastrol induced the expression of occludin and ZO-1) via activating MAPKs and PI3K/Akt/mTOR pathway. celastrol occludin Mus musculus