Title : Lack of the P2X7 receptor protects against AMD-like defects and microparticle accumulation in a chronic oxidative stress-induced mouse model of AMD.

Pub. Date : 2017 Jan 1

PMID : 27810364






1 Functional Relationships(s)
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1 Using multiple approaches, we demonstrate that Sod1 KO causes AMD-like defects, including positive staining for oxidative stress markers, 3-nitrotyrosine and carboxymethyl lysine, thinning of the RPE and retina, thickening of Bruch"s membrane, presence of basal laminar and linear deposits, RPE barrier disruption and accumulation of microglia/macrophages. N(6)-carboxymethyllysine superoxide dismutase 1, soluble Mus musculus