Pub. Date : 2016 Nov 15
PMID : 27799526
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prodigiosin blocked Wnt/beta-catenin signaling by targeting multiple sites of this pathway, including the low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL), and glycogen synthase kinase-3beta (GSK3beta). | Prodigiosin | glycogen synthase kinase 3 beta | Homo sapiens |
| 2 | Prodigiosin blocked Wnt/beta-catenin signaling by targeting multiple sites of this pathway, including the low-density lipoprotein-receptor-related protein (LRP) 6, Dishevelled (DVL), and glycogen synthase kinase-3beta (GSK3beta). | Prodigiosin | glycogen synthase kinase 3 beta | Homo sapiens |
| 3 | In breast cancer MDA-MB-231 and MDA-MB-468 cells, nanomolar concentrations of prodigiosin decreased phosphorylation of LRP6, DVL2, and GSK3beta and suppressed beta-catenin-stimulated Wnt target gene expression, including expression of cyclin D1. | Prodigiosin | glycogen synthase kinase 3 beta | Homo sapiens |