Title : Anti-inflammatory natural product goniothalamin reduces colitis-associated and sporadic colorectal tumorigenesis.

Pub. Date : 2017 Jan

PMID : 27797827






2 Functional Relationships(s)
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1 Additionally, GTN suppressed production of IL-6, IL-17 and TNF-alpha in tumor tissue, as well as abrogated stromal immune cell activation and nuclear translocation of NF-kappaB. goniothalamin interleukin 6 Mus musculus
2 Finally, in a tamoxifen inducible model of sporadic CRC, GTN-treated mice had significantly fewer tumors and decreased levels of IL-17A, IL-6, S100A9 and TNF-alpha protein within the tumors. goniothalamin interleukin 6 Mus musculus