Pub. Date : 2016 Oct 27
PMID : 27787197
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been shown to inhibit mTORC1 signaling. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | However, the mechanism by which lysosomal calcium regulates mTORC1 has remained undefined. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Herein we report that proper lysosomal calcium release through the calcium channel TRPML1 is required for mTORC1 activation. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Lysosomal calcium activates mTORC1 by inducing association of calmodulin (CaM) with mTOR. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | Moreover, CaM is capable of stimulating the kinase activity of mTORC1 in a calcium-dependent manner in vitro. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | These results reveal that mTOR is a new type of CaM-dependent kinase, and TRPML1, lysosomal calcium and CaM play essential regulatory roles in the mTORC1 signaling pathway. | Calcium | CREB regulated transcription coactivator 1 | Mus musculus |