Title : Synergistic effects of A-B-C-type amphiphilic copolymer on reversal of drug resistance in MCF-7/ADR breast carcinoma.

Pub. Date : 2016

PMID : 27785023






3 Functional Relationships(s)
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1 A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells. betadex ATP binding cassette subfamily B member 1 Homo sapiens
2 A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells. betadex ATP binding cassette subfamily B member 1 Homo sapiens
3 A series of studies on the action mechanism showed that the polymer components such as beta-cyclodextrin, hydrophobic poly(d,l-lactide) segment, and poly(ethylene glycol) coordinatively contributed to the improved intracellular ATP depletion and ATPase activity, increased intracellular uptake of P-gp substrates via competitive binding to P-gp, and decreased P-gp expression in MCF-7/ADR cells. betadex ATP binding cassette subfamily B member 1 Homo sapiens