Title : Mutant BRAF Upregulates MCL-1 to Confer Apoptosis Resistance that Is Reversed by MCL-1 Antagonism and Cobimetinib in Colorectal Cancer.

Pub. Date : 2016 Dec

PMID : 27765849






2 Functional Relationships(s)
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1 The small-molecule MCL-1 inhibitor, A-1210477, also enhanced cobimetinib-induced apoptosis in vitro that was due to disruption of the interaction of MCL-1 with proapoptotic BAK and BIM. A-1210477 MCL1 apoptosis regulator, BCL2 family member Homo sapiens
2 The small-molecule MCL-1 inhibitor, A-1210477, also enhanced cobimetinib-induced apoptosis in vitro that was due to disruption of the interaction of MCL-1 with proapoptotic BAK and BIM. A-1210477 MCL1 apoptosis regulator, BCL2 family member Homo sapiens