Pub. Date : 2017 Jan
PMID : 27764525
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | RESULTS: Celastrol attenuated Cd-induced apoptosis by suppressing Cd activation of mTOR, which was attributed to preventing Cd inactivation of AMPK. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Inhibition of AMPK with compound C or expression of dominant negative AMPKalpha prevented celastrol from hindering Cd-induced dephosphorylation of AMPKalpha, activation of mTOR and apoptosis. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | Inhibition of mTOR with rapamycin or knockdown of mTOR potentiated prevention by celastrol, of Cd-induced phosphorylation of p70 S6 kinase 1/eukaryotic initiation factor 4E binding protein 1 and apoptosis. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | Inhibition of mTOR with rapamycin or knockdown of mTOR potentiated prevention by celastrol, of Cd-induced phosphorylation of p70 S6 kinase 1/eukaryotic initiation factor 4E binding protein 1 and apoptosis. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | CONCLUSIONS AND IMPLICATIONS: Celastrol prevented the inactivation of AMPK by mitochondrial ROS, thus attenuating Cd-induced mTOR activation and neuronal apoptosis. | celastrol | mechanistic target of rapamycin kinase | Homo sapiens |