Pub. Date : 2017 Mar
PMID : 27757735
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 2 | Amsacrine-induced apoptosis of U937 cells was characterized by caspase-9 and caspase-3 activation, increased intracellular Ca2+ concentration, mitochondrial depolarization, and MCL1 down-regulation. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 3 | Amsacrine induced MCL1 down-regulation by decreasing its stability. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 4 | Restoration of ERK phosphorylation and AKT expression abrogated amsacrine-induced MCL1 down-regulation. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 5 | Moreover, MCL1 over-expression inhibited amsacrine-induced depolarization of mitochondria membrane and increased the viability of amsacrine-treated cells. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 6 | Moreover, MCL1 over-expression inhibited amsacrine-induced depolarization of mitochondria membrane and increased the viability of amsacrine-treated cells. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 7 | Taken together, our data indicate that amsacrine abolishes ERK- and Pin1-mediated stabilization of MCL1 and promotes GSK3beta-mediated degradation of MCL1, leading to activate mitochondria-mediated apoptosis pathway in U937 cells. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |
| 8 | Taken together, our data indicate that amsacrine abolishes ERK- and Pin1-mediated stabilization of MCL1 and promotes GSK3beta-mediated degradation of MCL1, leading to activate mitochondria-mediated apoptosis pathway in U937 cells. | Amsacrine | MCL1 apoptosis regulator, BCL2 family member | Homo sapiens |