Title : Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit.

Pub. Date : 2016 Dec 2

PMID : 27756840






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Fatty Acid Binding to the Allosteric Subunit of Cyclooxygenase-2 Relieves a Tonic Inhibition of the Catalytic Subunit. Fatty Acids prostaglandin-endoperoxide synthase 2 Homo sapiens
2 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids prostaglandin-endoperoxide synthase 2 Homo sapiens
3 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids prostaglandin-endoperoxide synthase 2 Homo sapiens
4 An S121P substitution in both PGHS-2 monomers yields a variant (S121P/S121P PGHS-2) that has 1.7-1.8 times the Vmax of native PGHS-2 and is relatively insensitive to activation by FAs or inhibition by allosteric inhibitors. Fatty Acids prostaglandin-endoperoxide synthase 2 Homo sapiens