Pub. Date : 2016 Dec
PMID : 27754784
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although rapid, androgen receptor-dependent activation of ERK has been postulated as a neurotrophic and neuroprotective mechanism, actions of T metabolites such as 5alpha-androstane-3alpha,17beta-diol (3alpha-diol) may also be involved. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | We investigated the influence of 3alpha-diol on the induction of ERK phosphorylation in SH-SY5Y human female neuroblastoma cells and primary cortical neurons from male and female mice. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The addition of 10 nM 3alpha-diol, which did not itself activate ERK, significantly inhibited ERK phosphorylation induced by DHT, epidermal growth factor, or H2O2, but not acetylcholine. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | In both SH-SY5Y cells and primary cortical neurons, prolonged ERK phosphorylation and caspase-3 cleavage resulting from amyloid beta-peptide 1-42 (Abeta42) exposure were inhibited by cotreatment with 3alpha-diol. | Androstane-3,17-diol | mitogen-activated protein kinase 1 | Homo sapiens |