Title : STAT3-targeted treatment with silibinin overcomes the acquired resistance to crizotinib in ALK-rearranged lung cancer.

Pub. Date : 2016 Dec 16

PMID : 27753543






1 Functional Relationships(s)
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1 Moreover, silibinin treatment significantly inhibited the upregulation of the immune checkpoint regulator PD-L1 and also EMT regulators (e.g., SLUG, VIM, CD44) in crizotinib-refractory cells. Crizotinib vimentin Homo sapiens