Pub. Date : 2016 Dec
PMID : 27751532
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockade of dorsal hippocampal orexin-1 receptors impaired morphine-induced state-dependent learning. | Morphine | hypocretin | Mus musculus |
| 2 | Pre-test administration of orexin-1 (0.5, 5 and 50pmol, intra-CA1) had not a significant effect on the retention latency compared to the saline-treated animals, but it restored the memory impairment induced by pre-training morphine (5mg/kg, i.p.). | Morphine | hypocretin | Mus musculus |
| 3 | Conversely, pre-test injection of SB-334867 (10, 20 and 40nmol, intra-CA1) inhibited the orexin-1-induced potentiation of morphine state-dependent learning on the test day. | Morphine | hypocretin | Mus musculus |
| 4 | It is concluded that dorsal hippocampal orexin-1 receptors may be involved, at least in part, in morphine state-dependent learning in mice. | Morphine | hypocretin | Mus musculus |