Title : Betulinic acid and the pharmacological effects of tumor suppression (Review).

Pub. Date : 2016 Nov

PMID : 27748864






1 Functional Relationships(s)
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1 The antitumor pharmacological effects of BA consist of triggering apoptosis via the mitochondrial pathway, regulating the cell cycle and the angiogenic pathway via factors, including specificity protein transcription factors, cyclin D1 and epidermal growth factor receptor, inhibiting the signal transducer and activator of transcription 3 and nuclear factor-kappaB signaling pathways, preventing the invasion and metastasis of tumor cells, and affecting the expression of topoisomerase I, p53 and lamin B1. betulinic acid epidermal growth factor receptor Homo sapiens