Pub. Date : 2016 Dec
PMID : 27746183
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we found a significant increase of hepatic PARP activity in mice with short-term and long-term ethanol-induced ALD. | Ethanol | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 2 | Furthermore, in vitro experiments found that LPS-induced macrophage activation was limited by PARP inhibitor, and exposure of ethanol-treated hepatocytes to this conditioned medium further decreased the number of apoptotic and steatotic cells. | Ethanol | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |
| 3 | Taken together, these findings suggest that PARP1 inhibition protects against long-term ethanol-induced liver injury, as indicated by limited hepatocytes steatosis, apoptosis, inflammation levels, and neutrophil infiltration, mainly by limiting KC activation during the initiation of ALD. | Ethanol | poly (ADP-ribose) polymerase family, member 1 | Mus musculus |