Title : S-nitrosation on zinc finger motif of PARP-1 as a mechanism of DNA repair inhibition by arsenite.

Pub. Date : 2016 Dec 6

PMID : 27741521






2 Functional Relationships(s)
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Protein Name
Organism
1 AsIII-induced ROS lead to oxidation of cysteine residues within the PARP-1 zinc finger DNA binding domain. Cysteine poly(ADP-ribose) polymerase 1 Homo sapiens
2 In this work, we demonstrate that AsIII treatment of normal human keratinocyte (HEKn) cells induced S-nitrosation on cysteine residues of PARP-1 protein, in a similar manner to a nitric oxide donor. Cysteine poly(ADP-ribose) polymerase 1 Homo sapiens