Title : Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α.

Pub. Date : 2016 Nov 25

PMID : 27738106






4 Functional Relationships(s)
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1 We report here that liver BVRA protects against hepatic steatosis by inhibiting glycogen synthase kinase 3beta (GSK3beta) by enhancing serine 9 phosphorylation, which inhibits its activity. Serine glycogen synthase kinase 3 beta Mus musculus
2 We report here that liver BVRA protects against hepatic steatosis by inhibiting glycogen synthase kinase 3beta (GSK3beta) by enhancing serine 9 phosphorylation, which inhibits its activity. Serine glycogen synthase kinase 3 beta Mus musculus
3 We show that GSK3beta phosphorylates serine 73 (Ser(P)73) of the peroxisome proliferator-activated receptor alpha (PPARalpha), which in turn increased ubiquitination and protein turnover, as well as decreased activity. Serine glycogen synthase kinase 3 beta Mus musculus
4 We show that GSK3beta phosphorylates serine 73 (Ser(P)73) of the peroxisome proliferator-activated receptor alpha (PPARalpha), which in turn increased ubiquitination and protein turnover, as well as decreased activity. Serine glycogen synthase kinase 3 beta Mus musculus