| Protein Name | glycogen synthase kinase 3 beta |
|---|---|
| Organism | Mus musculus |
| Gene ID | 56637 |
| Gene Symbol | Gsk3b |
| UniProt | Q9WV60 (GSK3B_MOUSE), Q5KU03 (Q5KU03_MOUSE), E9QAQ5 (E9QAQ5_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
814
Total Number of Articles : 1369 |
Description |
glycogen synthase kinase 3 beta |
| Gene Summary |
Enables several functions, including beta-catenin binding activity; dynein complex binding activity; and protein kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of signal transduction; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; positive regulation of nitrogen compound metabolic process; and regulation of neuron projection development. Located in several cellular components, including dendritic shaft; glutamatergic synapse; and postsynaptic density. Part of Wnt signalosome; beta-catenin destruction complex; and ribonucleoprotein complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; immune system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022] |
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