Pub. Date : 2017 Oct
PMID : 27730514
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intranasal Insulin Administration Ameliorates Streptozotocin (ICV)-Induced Insulin Receptor Dysfunction, Neuroinflammation, Amyloidogenesis, and Memory Impairment in Rats. | icv | insulin | Homo sapiens |
| 2 | Moreover, intranasal insulin was found to inhibit significantly glial cell activation (GFAP and Iba-1 expression), neuroinflammation (COX-2 expression, NFkappaB translocation, TNF-alpha, and IL-10 level) and amyloidogenic protein expression (BACE-1 and Abeta1-42 expression) in STZ (ICV)-injected rats. | icv | insulin | Homo sapiens |
| 3 | STZ (ICV)-induced caspase activation and postsynaptic neurotoxicity were also prevented by treatment with intranasal insulin. | icv | insulin | Homo sapiens |
| 4 | Graphical Abstract Neuroprotective effects of intranasal insulin administration on streptozotocin (ICV)-induced memory impairment in rats. | icv | insulin | Homo sapiens |