Title : Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity.

Pub. Date : 2016 Sep

PMID : 27722009






1 Functional Relationships(s)
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1 Finally, loss of SIRT3 in cisplatin-exposed cells removed the protective effect of PARP1 inhibition against oxidative stress, represented by the concentration of lipid hydroperoxide and 8-hydroxy-2"-deoxyguanosine; and necrotic cell death represented by a percentage of propidium iodide-positively stained cells. Propidium poly(ADP-ribose) polymerase 1 Homo sapiens