Title : Inhibition of insulin-like growth factor II (IGF-II)-dependent cell growth by multidentate pentamannosyl 6-phosphate-based ligands targeting the mannose 6-phosphate/IGF-II receptor.

Pub. Date : 2016 Sep 20

PMID : 27694692






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) binds M6P-capped ligands and IGF-II at different binding sites within the ectodomain and mediates ligand internalization and trafficking to the lysosome. alpha-D-mannose 6-phosphate insulin like growth factor 2 Homo sapiens