Title : EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.

Pub. Date : 2016 Oct

PMID : 27694161






2 Functional Relationships(s)
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Protein Name
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1 Erlotinib, a selective EGFR inhibitor, enhanced AQP2 apical membrane expression in collecting duct principal cells and reduced urine volume by 45% after 5 days of treatment in mice with lithium-induced NDI. Erlotinib Hydrochloride aquaporin 2 Mus musculus
2 Erlotinib increased phosphorylation of AQP2 at Ser-256 and Ser-269 and decreased phosphorylation at Ser-261 in a dose-dependent manner. Erlotinib Hydrochloride aquaporin 2 Mus musculus