Pub. Date : 2016 Nov
PMID : 27665868
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. | ursolic acid | tumor protein p53 | Homo sapiens |
| 2 | UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. | ursolic acid | tumor protein p53 | Homo sapiens |
| 3 | Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1. | ursolic acid | tumor protein p53 | Homo sapiens |
| 4 | Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53. | ursolic acid | tumor protein p53 | Homo sapiens |