PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27665868-9 2016 UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. ursolic acid 0-2 tumor protein p53 Homo sapiens 37-40 27665868-9 2016 UA increases the expression level of p53 in a concentration-dependent manner, and inhibition of p53 reduces the anticancer effect of UA in 143B cells. ursolic acid 133-135 tumor protein p53 Homo sapiens 96-99 27665868-10 2016 Moreover, inhibition of p53 partly reverses the UA-induced downregulation of beta-catenin, as do the targets of Wnt/beta-catenin signaling, such as c-Myc and cyclin D1. ursolic acid 48-50 tumor protein p53 Homo sapiens 24-27 27665868-11 2016 Our findings indicated that UA can inhibit the proliferation of 143B OS cells through inactivation of Wnt/beta-catenin signaling, which may be mediated partly by upregulating the expression of p53. ursolic acid 28-30 tumor protein p53 Homo sapiens 193-196