Pub. Date : 2016 Dec
PMID : 27657826
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Anti-inflammatory activities of fenoterol through beta-arrestin-2 and inhibition of AMPK and NF-kappaB activation in AICAR-induced THP-1 cells. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | We reported that fenoterol, a beta2-adrenergic receptor (beta2-AR) agonist, inhibited lipopolysaccharide (LPS)-induced AMPK activation and inflammatory cytokine production in THP-1 cells, a monocytic cell line in previous studies. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | AICAR-induced AMPK activation, NF-kappaB activation and tumor necrosis factor (TNF)-alpha release were reduced by fenoterol. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | In addition, siRNA-mediated knockdown of beta-arrestin-2 abolished fenoterol"s inhibition of AICAR-induced AMPK activation and TNF-alpha release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol in AICAR-treated THP-1 cells. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 5 | In addition, siRNA-mediated knockdown of beta-arrestin-2 abolished fenoterol"s inhibition of AICAR-induced AMPK activation and TNF-alpha release, thus beta-arrestin-2 mediated the anti-inflammatory effects of fenoterol in AICAR-treated THP-1 cells. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 6 | These data suggested that fenoterol inhibited AICAR-induced AMPK activation and TNF-alpha release through beta-arrestin-2 in THP-1 cells. | Fenoterol | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |