Title : Human Parturition Involves Phosphorylation of Progesterone Receptor-A at Serine-345 in Myometrial Cells.

Pub. Date : 2016 Nov

PMID : 27653036






2 Functional Relationships(s)
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1 The hypothesis that phosphorylation of progesterone receptor (PR) isoforms, PR-A and PR-B, in myometrial cells affects progesterone action in the context of human parturition was tested. Progesterone RB transcriptional corepressor 1 Homo sapiens
2 Prevention of pSer345 (by site-directed mutagenesis) abolished the capacity for PR-A to inhibit anti-inflammatory actions of progesterone mediated by PR-B but had no effect on the transrepressive activity of PR-A at a canonical progesterone response element. Progesterone RB transcriptional corepressor 1 Homo sapiens