Pub. Date : 2016
PMID : 27648839
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, some reports show that overexpression of TSG101 inhibits virus release by disruption of Gag targeting process. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 2 | Co-transfection of TSG101 and Gag with Vpr prevented TSG101-induced Gag accumulation in endosomes and lysosomes. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 3 | Vpr and Gag interaction is required to counteract TSG101 overexpression effect since Vpr A30F mutant which is unable to interact with Gag and incorporate into virions, reduced ability to prevent Gag accumulation and to rescue VLP production. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 4 | Vpr and Gag interaction is required to counteract TSG101 overexpression effect since Vpr A30F mutant which is unable to interact with Gag and incorporate into virions, reduced ability to prevent Gag accumulation and to rescue VLP production. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 5 | Vpr and Gag interaction is required to counteract TSG101 overexpression effect since Vpr A30F mutant which is unable to interact with Gag and incorporate into virions, reduced ability to prevent Gag accumulation and to rescue VLP production. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 6 | In addition, GST pull-down assays and Biacore analysis revealed that Vpr competed with TSG101 for Gag binding. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 7 | These results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |
| 8 | These results indicate that Vpr overcomes the effects of TSG101 overexpression to support viral production by competing with TSG101 to bind Gag. | Glycosaminoglycans | tumor susceptibility 101 | Homo sapiens |