Title : DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer.

Pub. Date : 2016 Sep 15

PMID : 27634334






1 Functional Relationships(s)
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1 Chemical and cytotoxic induction of replication stress, through aphidicolin, gemcitabine, camptothecin or hydroxyurea exposure, activates transcription of APOBEC3B via an ATR/Chk1-dependent pathway in vitro. Camptothecin ATR serine/threonine kinase Homo sapiens